Wonderful info from all who have posted. Thank you so much for your help.
As I noted I have my tickets now and arrive on Wednesday morning in Ontario at roughly 10. We are now discussing whether or not we should try for permits on both Friday and Saturday.
This would increase our chances of getting a permit. But if we get the one for Friday it also means one less day of acclimizing.
As it is, my plan is to get from Ontario to Horseshoe Meadows as quick as possible and either hike around some or just read a book.
I'm also setting up a doctors appointment to get some Diamox.