Neither the sources "pharcopia" or average PCPs are recognized as knowledgeable about high altitude illnesses.
A dose of 1000 mg day Diamox will guarantee side effects, especially paresthesias, and without added benefit above appropriate doses.
Most high altitude sources recommend 125 twice daily, or at most 250 twice daily and even that is very likely to cause side effects. In the actual field, most of us in expedition medicine suggest 125 twice daily.
please see reputable source, one of which is:
International Society for Mountain Medicine Acetazolamide Use & Dosage:
For treatment of AMS
We recommend a dosage of 250 mg every 12 hours.
For Periodic Breathing
125 mg about an hour before bedtime.
