Thanks for these thoughts. In terms of prevention, I am going the slow acclimatization route (2 days, three nights at 9,000 plus feet, with day hikes higher, before tackling the main trail) rather than the drug-as-prophylactic route, a personal decision to be sure.
But does anyone have a suggestion for a doctor with high altitude knowledge in the SF Bay Area? I am thinking a consult might be worthwhile given that my hiking plan this summer will be significantly kicking it up a notch.