As an endurance marathon runner, I feel your pain. I failed on an attempt with my father a couple years ago. I am beginning to think more and more that unless you can really acclimatize fully (meaning slowly, hike high camp low) there really isn't much you can or should even bother trying to do. Maybe you would have been better off resting than hiking at Horseshoe Meadows.
So unless you have a lot of time to use on a vacation, I'm convinced that crossing your fingers and taking Diamox is the best strategy.
