I took diamox last year. I took it at home at first, a couple of weeks before Whitney. I believe I was told to take 2 x 125 daily, which was too much for me (185 lbs). I ended up taking 62.5 before bedtime after scaling it back a couple of times. I seemed to do okay with that doseage and had less problems with AMS (or what I perceived to be AMS) on Whitney than I did on San Jacinto (10,800 ft).