Wow, we've seen a lot of trip reports here of people getting sick, really sick, from that much Diamox. That may be the dosage for glaucoma...the doctors on this board may opine.
A high-altitude specialist prescribed Diamox for me (female, 140 lbs) at 62.5 mg twice a day. Through trial and error, I found even that reduced dose to be far too much for me. Now, for the Eastern Sierras, I take 62.5 mg before bed on the first one or two nights sleeping above 11,000'. I do not otherwise take it. (On Kili, I ended up taking more when we were at 16,000', but that's a different story.)
I also carry heavy duty electrolytes. Sometimes, even at that reduced dosage, I run into trouble (excessive peeing) and one or two does of electrolytes fixes the problem real fast.
A male friend of mine (180 lbs) takes 125 mg Diamox once a day before bed. That's what he took on our Onion Valley-Whitney hike (6 days), worked well for him. He started out at 125 mg twice a day, but, yes, ran into electrolyte trouble and then halved his dosage to 125 mg once a day.
These are our experiences. Your experience may differ, of course. Take this and anything else you read on the internet with a healthy dose of skepticism.
