Re: Brisket disease. Interesting similarities with humans and AMS: Between different individuals, the susceptibility varies markedly.
From this source on Brisket disease (High-mountain Disease: Introduction)
Quote:
The role of genetics in high-mountain disease is supported by high familial incidence with marked variation in susceptibility between animals and between species


Re: AMS and Diamox. The Altitude Tutorial recommends 125-250 mg twice a day. I myself have used the 125 twice a day for Mt Whitney ascents. There are some people who use less -- 62.5 mg once or twice a day.

Akichow gave some interesting information on her personal experience on her Kilimanjaro Trip report (Jan. 8-17, 2012), where she was using 62.5 mg once a day, and after experiencing more serious AMS symptoms, increased to 62.5 mg 4 times per day with good results.