I guess I should reiterate that I've never had a bad AMS problem in the first place - persistent headache, low of appetite (I consider that a benefit smile ), and difficulty sleeping. Before finding these canisters, I made it up and down 14er's with just aspirin, and I adjust pretty quickly to backpacking at high elevation. So my anecdotal experience with a canister is just one point on the graph - it does not apply to someone who has more difficulty with elevation. I seem to be marginally susceptible and a canister tips the scales just enough for me. I'm confident others would feel a benefit, but maybe not enough, and maybe someone would push themselves further up the mountain than they otherwise should. I'm not advocating, just sharing my experience.