As for Diamox and AMS...everyone is different. 125 mg. twice a day is a good starting point for someone just starting to use the drug. I am adversely affected by taking this drug that way.
In my small sampling, friends and acquaintances, I have found everyone is affected differently...I have zero problems day hiking to SoCal high peaks but some of my friends are debilitated walking up the Ski Hut Trail to Mt. Baldy. I have had problems as low as 7,500' overnight and regularly AMS problems while taking Diamox.
There are no cookie cutter solutions to this problem. It takes time to figure out what dosing regiment works best for you.