My brother and I were both prescribed Diamox 250mg/2 x day, 500 mg total a day starting the day before arriving in elevation...could it have been overkill? I don't know, but our plan was to take as many variables out of play that we could to give us the best chance to summit (which we did). We both came from sea level and acclimated one night at Horseshoe Meadows (10,000ft) and one night at the Portal and had zero issues with altitude and we were also very well hydrated and very well fed! :-) Also, a good idea may be try it out days prior to gauge your reaction or lack there of to it.
This is certainly not the universal formula here, because everything differs when it comes to different people, medications, circumstances, age, conditions, etc...but personally, I don't like to leave home without it and take the chance of having issues up there. Good luck this year!
Last edited by Jrod8; 08/04/11 07:11 PM.