Elaborating on what Steve said…
The correct dose of any medication is the lowest dose that is effective. On the other hand, increasing the dose beyond recommendations can be dangerous. Larger doses may be appropriate for glaucoma, but 125mg twice a day is the usual recommendation for AMS. Taking more than that increases side effects with little or no benefit.
Be sure that you are taking good care of your body in other ways: acclimatization, food, sleep, and plenty of conditioning before starting up. Food, water, and a reasonable pace while hiking. And don’t breathe air that’s full of ash or that you can’t see through.
“Happy Trails†brought a pulse oximeter on a couple of our dayhikes. My reading was 92 on top of Middle Palisade and 89 on Whitney. Curious what it would have been on Denali; I felt pretty good.
