By the way, I don't start diamox until the night that I reach altitude. For me, it is fast acting (in about an hour). Based on my sex and weight, a high altitude specialist/wilderness medicine doctor at Stanford whom I consulted a few ago recommended 62.5 mg twice a day for me. In the Sierra, I only need 62.5 mg once a day (right before sleeping); at higher altitudes, I need more. That's me. Your experience may differ. I've also discussed these issues with Harvey and appreciate his knowledge re high altitude medicine and willingness to share his thoughts.