You are right everyone is different.
San Jacinto and San Gorgonio may not provide you with the information you seek. I can hike both without AMS problems but the Sierra is another issue entirely...for me.
When you start and what dose is also personal but there are standard dosing guidelines...see Dr. Peter Hackett for good information. He will provide you with a base line; however, only experience will provide you with a when and a dosing schedule.
