Conference alignments have killed some very historic natural rivalries (Oklahoma/Nebraska being foremost), but with a 12-game schedule now there's absolutely no reason for natural rivals in separate conferences not to play annually. Pitt has 7 conference games and Penn State 8, so plenty of room to schedule it every year. Each year 3 teams from the SEC play in-state rivals from the ACC - Georgia, South Carolina and Florida play Georgia Tech, Clemson and Florida State respectively. Kentucky (SEC) plays Louisville (Big East) annually, as do Iowa (Big 10) and Iowa State (Big 12). Notre Dame and USC find the time to play each other every year, and there's no legitimate reason for that other than tradition.
So I'm guessing Joe Pa is too attached to the Akrons, Coastal Carolinas and Florida Internationals that litter Penn State's open schedule slots to waste time on old, boring Pitt/PSU . . .
And yeah, Bee is rockin' on!