As I speculated above, and Ken confirmed, I think they need to do better research on these alternatives. This study is surprisingly sloppy coming from Stanford and UCSD.
Gingko Biloba keeps looking like a possible contender. I used it one time on Shasta, but I've never had AMS very bad anyway. Here are links to some studies on the reported benefits of using Gingko Biloba to prevent AMS. Again, small number of subjects involved to make statistical comparisons, and nothing works for everyone.
The first study used 12 subjects in 3 groups, Gingko, Diamox, and Placebo in Northern Chile. Treatment started 1 day in advance, which is a short window for the Gingko to take effect. The group taking the Gingko apparently did the best of the three.
Gingko Biloba 1-day prior to ascent A second link is an article that reports on a study on Pike's Peak where 40 students took either Gingko or Placebo 5 days in advance. 7/20 got AMS with Gingko vs 13/19 without, and the severity was less with Gingko.
Pike's Peak Students on Gingko Biloba The study was conducted by Dr. Peter Hackett, who's got lots of experience on Mt Everest and is a regular contributor to the website (Everestnews.com). He also refers to a French study on Gingko. He wrote,
"I would especially recommend it [Gingko Biloba] for those situations in which I might consider Diamox: abrupt ascent, past history of AMS, and those who really need to avoid AMS for various reasons, like diabetes, lung disease, maybe pregnancy, etc. If it didn't work, and Diamox was felt necessary, no problem, you could give Diamox." Dr. Peter Hackett, MD
Gingko increases blood flow which helps circulation. Those taking Gingko [in the French study] reported significantly warmer hands and feet, according to Dr. Hackett.
Gingko has been shown to be helpful for those with dementia also. Did I mention it might help with dementia? It can also help with dementia, but they need more study. Some studies say it might help with dementia. I think I'll take some right now...
