Bee is right about lugging oxygen. On Diamox, if I do not take any I get a massive headache, if I take the usual half doses that most people recommend I get a slight headache that I can deal with. It will usually hit me on the way down from the summit during the switchbacks. I live in the desert and its hard to acclimate, I try to get there a couple of days early and hit Horseshoe Meadow and White Mountain and I think it helps a little. In my opinion proper acclimatisation is better than Diamox but I just try a little of both.