I wonder about diamox too. Both times I've taken it I started at least 24 hours prior to ascent, however I notice I feel "off" from the diamox itself (125mg twice daily) before even getting to the mountain.
Anyone here try day hiking/ rapid ascent with and without diamox?
This last time, i stopped taking it during descent.
Try taking half the 125 mg twice a day. I'd end taking it once at the summit, too.
There are a few people who can day hike Whitney with the rapid ascent with no altitude preparations, and they do just fine.