I've used Diamox a few times before, and it's helped and I was a big fan at first. However, I've found that the side effect outweighs the benefit sometimes, mainly the frequent need to urinate. I keep a few pills if I'm going to be in the Sierra as a backup, but not as a preventative medicine.

I've recently taken CoQ10 with some good results. I don't know if it'll work for you but it's worth a try. Available at your local Costco or online through Amazon:
http://www.costco.com/Qunol%E2%84%A2-Mega-CoQ10-100-mg-Ubiquinol,-120-Softgels.product.11630572.html