That dosage of 250 mg twice a day is the upper limit of dosage for AMS. I have seen others say they got by on 1/2 to 1/4 of that level.
I was prescribed 250 mg twice per day. The pills are 125 each I believe. I break them and take 1/2 twice per day.
I have suffered mild AMS symptoms (headache) a few times. In my very limited experience, I'd say that rate of ascent is the most important factor for me.
- Doing San Jacinto via the tram gets me every time, but I when I did C2C I didn't have symptoms.
- I've done San G (higher than San Jacinto) 3 times (fish creek x 2, south fork), but no headache
- First time I did Whitney, we spent time at Schulman Grove to acclimate. I summitted in 9 hrs with a headache. 2nd Whitney trip - no acclimation hike, only 3 hrs of sleep, summitted in 11+ hrs with no headache
- I usually get a mild headache doing Baldy via Baldy Bowl/Ski Hut. The two times I did it via Bear Canyon, no headache