Bob, very interested on what some of the ultra runners from Bishop have to say in general about the run. Nutrition is a big thing that I am currently playing around with to make sure I'm fueled for the run.
As I said earlier, we did the JMT as a hike and ended up carrying one week's worth of food out of Mammoth. My son, who does not have an extra ounce on his body, ate more than I have ever seen him eat. I was definitely running a caloric deficit, because one can carry only so much food. Running and cutting off a few days would help on total weight, but you also need to have enough calories to keep going. If I was going to run a significant portion of the trail, I would think seriously about having a support crew. On the other hand, the JMT has been done in many ways!